Gebruiksaanwijzing plamitoylethanolamide (PEA)

gebruiksaanwijzing

Gebruiksaanwijzing palmitoylethanolamide (PEA): wat het is en hoe te gebruiken

Een natuurlijke en lichaamseigen pijnstiller, die in Nederland al door vele tienduizenden patiienten als supplement gebruikt is, is palmitoylethanolamide (PEA). Het supplement is in Nederland verkrijgbaar als capsules en als PEA creme.

Belangrijke aanwijzing: U wilt hoge zuiverheid (100%): check dat altijd en kies geen onduidelijk preparaat want daarmee doet u uzelf tekort! Vraag daarom altijd naar het onderzoeks-/kwaliteitsrapport.

PEA: natuurlijk middel en veel wetenschap

Palmitoylethanolamide is een natuurlijke, lichaamseigen pijnstiller en ontstekingsremmer, waarvan de werking ontdekt is in 1993 door de beroemde professor Rita Levi-Montalcini, een Nobelprijs winnares, die in 2012 op 103-jarige leeftijd overleed.

PEA is sinds 1970 bij vele duizenden patienten in klinische studies getest op werking en bijwerking. De pijnstilling is bij velen indrukwekkend en het middel heeft geen problematische, noch ernstige bijwerkingen. Het is ook goed samen met andere geneesmiddelen en pijnstillers te gebruiken. We zullen hier dan ook achtergronden bespreken en een gebruiksaanwijzing geven.

 PEA:  informatie voor uw arts

Het pure PEA is een supplement en dus zonder recept verkrijgbaar. Het is zeer verdraagbaar in tegenstelling tot de meeste pijnstillers. Wel heeft het enige tijd nodig, omdat het de pijn via een biologische weg aanpakt.

Voor uw arts hebben we speciaal alle wetenschap over PEA verzameld in een kort overzicht. Dat kan u uitdrukken en meenemen voor uw arts.

Voor een beschrijving van hoe onze patienten het doen op palmitoylethanolamide is er ook een overzicht uit eind 2012:

Keppel Hesselink JM, Hekker TA, Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series. Journal of Pain Research 2012 Volume 2012:5 Pages 437 – 442

Dit artikel is makkelijk te downloaden en kunt u ook aan uw behandelend arts geven.

Chronische pijn en chronische ontstekingen behandelen is nog steeds een probleem. Veel patienten vinden geen baat bij de bekende pijnstillers en de bijwerkingen beperken het gebruik.

Er is daarom ook een grote zoektocht in de geneeskunde naar hoe neuropathische pijn (of zenuwpijn) en chronische pijn te behandelen is, zonder de lastige bijwerkingen van pijnstillers zoals gabapentine, pregabaline en amitriptyline. Zonder sufheid dus, zonder dat zombie-gevoel waar veel van onze patienten over klagen.

Sinds 2008 een doorbraak op dit gebied, want PEA is als nieuw middel beschikbaar gekomen. Het is een voedingssupplement en tegelijkertijd een bijzonder pijnstillende en een lichaamseigen stof. Een met goede pijnstillende werking bij verschillende ernstige pijnsyndromen, van hernia pijn tot en met de venijnige voetpijn bij diabetes. Een kort verhaal over een uitzonderlijke stof.

PEA geeft geen problematische bijwerkingen, omdat het een lichaamseigen stof is, en het kan het samen met andere geneesmiddelen zonder problemen ingenomen worden; interacties zijn niet bekend.

Omdat PEA een lichaamseigen stof is, die in principe dus (vrijwel) geen bijwerkingen heeft, en het ook zo goed werkzaam is, laten patiënten die wij in ons instituut zien ons weten, dat ze het veel prettiger vinden om in te nemen dan bijvoorbeeld amitriptyline en Lyrica en dat soort farmaceutische middelen, die je vaak suf maken. Symptomen die optreden tijdens PEA gebruik kunnen samenhangen met of het middel zelf, of met de ziekte. Dat beoordelen is een rol van de behandelende arts. In het algemeen zijn er geen klinisch relevante bijwerkingen gemeld.

PEA: veiligheid, werkzaamheid en eigenschappen

Deze pijnstiller heeft een aantal belangrijke en interessante eigenschappen en aspecten:

  1. Ingezet bij meer dan een miljoen patienten in Europa en vele duizenden in Nederland.
  2. Beschikbaar als zuivere stof in capsules alsmede in een creme (tegen eczemen en huidpijnen)
  3. Getest in studies bij duizenden patienten met pijnen en ontstekingen, waaruit de pijnstillende en ontstekingsremmende werking blijkt.
  4. Onderzocht bij griep en verkoudheid, waar het door de anti-ontstekingswerking de ernst van de griep vermindert.
  5. Onderzocht in honderden studies door biologen en farmacologen: nooit eerder werd een supplement zo uitvoerig bestudeerd.
  6. Werkzaamheid en veiligheid onderzocht bij o.a. herniapijnen, diabetische neuropathische pijnen, chronische kaakpijnen, carpaal tunnelsyndroom, trigeminusneuralgie. gordelroospijn en eczemen.
  7. Makkelijk te gebruiken, als poeder onder de tong voor de beginbehandeling en als capsules (of tabletten) daarna.
  8. Zonder problemen in te nemen naast andere geneesmiddelen en pijnstillers.
  9. Goede pijnstilling, soms zelfs beter dan bekende pijnstillers zoals ibuprofen en Lyrica.
  10. Gemelde bijwerkingen zijn minimaal, gebruik uiterst patientvriendelijk.
  11. Ook effectief en patientvriendelijk bij oude en zelfs heel oude patienten.
  12. En tenslotte: PEA is een lichaamseigen stof, we produceren deze stof zelf in onze cellen waar het werkt als natuurlijke pijnstiller en ontstekingsremmer.

Ons lichaam maakt zelf palmitoylethanolamide

Het boeiende van het hele PEA-verhaal is, dat ons lichaam deze pijnstillende stof dus zelf maakt, in de cellen van ons lichaam. Zowel in de zenuwcellen als in de bindweefselcellen vindt er doorlopend een opbouw van vetten plaats in palmitoylethanolamide (PEA).

PEA speelt namelijk een belangrijke biologische rol bij veel verschillende levensprocessen, waaronder ontstekingen en bij pijnen. We produceren bij een ontsteking en bij pijn dus onze eigen pijnstiller en ons eigen anti-ontstekingsmiddel. Maar bij ernstige pijnen en ontstekingen is dat dus duidelijk niet voldoende.

Dan is het zinvol om via de voeding extra van deze stof PEA tot ons te nemen, zodat de pijnstillende en ontstekingsremmende reservoirs in ons lichaam aangevuld kunnen worden.

Gebruiksaanwijzing Pea: advies dosering en gebruik

Gebruiksaanwijzing PeaPure: begin met 3 maal daags 400 mg PeaPure

Gebruiksaanwijzing begin met 3 maal daags 400 mg PEA

Neem de eerste maand ten minste 1200 mg PEA per dag, bijvoorbeeld s’ochtends 2 capsules 400 mg pure PEA and s’avonds 1 capsule. Tijdens of na de maaltijd innemen.

Meestal start de pijnstilling binnen enkele dagen tot weken. Als na 3-4 weken de pijn niet duidelijk afgenomen is, verhoog de dosering. Bijvoorbeeld naar drie maal daags 2 capsules.

Bij hele ernstige pijnen, zoals pijn na een beroerte of bij Sudeck adviseren we meteen om de dosis te verhogen, naar 2 maal 2 capsules of drie maal 2 capsules gedurende ten minste een maand. Begin op dag een wel gewoon met drie maal daags 1 capsule (instappen heet dat).

Dosering: stap voor stap

Begin de eerste maand met 1200 mg PEA per dag (3 capsules). Bij onvoldoende resultaat hoog de dosis op naar 3 maal 2 capsules per dag. Gebruik het middel dan nog een maand, als de pijn duidelijk minder wordt, verlaag de dosering dan na 2 maanden tot het niveau waarbij de pijnstilling bemerkbaar blijft. Sommige mensen kunnen goed uit de voeten met 2 maal 2 capsules per dag, anderen bijvoorbeeld met 2 of 3 maal 1 capsule per dag.

Als de pijn na 2-3 maanden nog niet gereageerd heeft, dan is het beter te stoppen met PEA, dan bent u een zogenaamde non-responder.

Waar kan men PEA bestellen?

Op onze website onder het kopje ‘shopping’  kunt u producten met PEA bestellen.

Pea: vrij van sorbitol en magnesium stearaat en andere chemische stoffen

In een Italiaans PEA middel zit sorbitol, en sorbitol kan aanleiding zijn tot een aantal bijwerkingen, zoals diarree, opgezwollen buik, borrelingen en buikpijnen. Dat komt omdat een aantal mensen dit suiker niet goed kunnen verteren, en we citeren: Malabsorption of carbohydrates such as …sorbitol can often be detected among patients suffering from so-called non specific abdominal complaints. So far successful treatment consists of dietary interventions only.  [17]

Magnesium stearaat is een niet natuurlijke stof die aan tabletten toegevoegd wordt, om ze makkelijker te kunnen produceren. We citeren:

Magnesium stearate may make it easier for machines to eject tablets, but it can also make it harder for bodies to absorb nutrients. “Bioavailability” refers to your body’s ability to absorb and utilize nutrients. According to research conducted at Rutgers University, too high an amount of magnesium stearate may decrease the bioavailability of the substance that the tablet is meant to deliver.

De stof magnesium stearaat kan dus de werking van PEA verminderen, doordater minder opgenomen wordt.

In het Nederlandse PEA preparaat zit noch sorbitol noch magnesium stearaat, noch andere biologisch zinloze stoffen, en dat zou dus wel eens belangrijke voordelen kunnen zijn. Er zijn zelfs bronnen die zelfs waarschuwen tegen magnesium stearaat, omdat het ook medische nadelen zou hebben. Hoewel we niet kunnen uitsluiten dat ook daar weer economische motieven meespelen, is het goed te weten dat het nieuwe middel Nederlandse middel geheel vrij is van magnesium stearaat, sorbitol en andere farmaceutische stoffen.

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